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Authored: Lorca, T, Castro, A, 2006-01-26 00:00:00,
Edited: Matthews, L, 2006-01-30 00:00:00,
Emi1 destruction in early mitosis requires the SCF�²TrCP ubiquitin ligase complex. Binding of �²TrCP to Emi1 occurs in late prophase and requires phosphorylation at the DSGxxS consensus motif as well as Cdk mediated phosphorylation. A two-step mechanism has been proposed in which the phosphorylation of Emi1 by Cdc2 occurs after the G2-M transition followed soon after by binding of �²TrCP to the DSGxxS phosphorylation sites. Emi1 is then poly-ubiquitinated and degraded by the 26S proteasome.,
Reviewed: Peters, JM, 2006-03-27 22:55:09
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SCF-beta-TrCP mediated degradation of Emi1
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