| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
The E2F family of transcription factors regulate the transition from the G1 to the S phase in the cell cycle. E2F activity is regulated by members of the retinoblastoma protein (pRb) family, resulting in the tight control of the expression of E2F-responsive genes. Phosphorylation of pRb by cyclin D:CDK complexes releases pRb from E2F, inducing E2F-targeted genes such as cyclin E.
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| biopax3:xref | |
| biopax3:dataSource | |
| biopax3:displayName |
G1/S-Specific Transcription
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| biopax3:organism | |
| biopax3:pathwayComponent |