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| biopax3:comment |
Authored: Gilleron, J, Segretain, D, Falk, MM, 2007-01-03 12:23:09,
Edited: Matthews, L, 2007-04-12 12:57:50,
Following connexon oligomerization, the hemichannels must be transported to the plasma membrane. This has been shown to occur in transport vesicles called "cargo containers". Most of post-Golgi cargo containers have a diameter of of 50- 200 nm (Lauf et al., 2002). Recently direct transport of connexins to GJ assembly sides has been described (Shaw et al., 2007). Besides microtuble-dependent trafficking, a microtubule-independent delivery pathway may exist as concluded from studies using the secretory transport inhibitor, Brefeldin A (Musil and Goodenough 1993; De Sousa et al. 1993; Laird et al. 1995).
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| biopax3:xref |
http://identifiers.org/pubmed/12149451,
http://identifiers.org/pubmed/17289573,
http://identifiers.org/pubmed/7691412,
http://identifiers.org/pubmed/8404537,
http://identifiers.org/pubmed/8522583,
urn:biopax:UnificationXref:REACTOME DATABASE ID_190872,
urn:biopax:UnificationXref:REACTOME_REACT_11050_2
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| biopax3:dataSource | |
| biopax3:displayName |
Transport of connexons to the plasma membrane
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| biopax3:organism | |
| biopax3:pathwayComponent | |
| biopax3:pathwayOrder |