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biopax3:comment |
Authored: Shamovsky, V, 2011-03-16,
Edited: Shamovsky, V, 2011-08-12,
Reviewed: Gillespie, ME, 2011-08-19,
TIR-domain-containing adaptor inducing interferon-beta (TRIF or TIKAM1) is known to be an essential and exclusive adaptor used by TLR3; all the poly(I:C)-induced pathways leading to NFkB and IRF3 activation were abolished in TRIF?/? mice (Yamamoto et al. 2003).
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biopax3:displayName |
TRIF mediated TLR3 signaling
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biopax3:pathwayOrder |