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| biopax3:comment |
Authored: Le Novere, N, Jassal, B, 2004-03-31 12:22:05,
Edited: Jassal, B, 2008-11-06 10:17:49,
Receptor activated heterotrimeric G proteins consist of the Galpha and the tightly associated Gbeta-gamma subunits. When a ligand binds to a G protein-coupled receptor, it stabilises a conformation with an high affinity for the G-protein bound to GDP. GDP is then exchanged for GTP on the Galpha subunit. This exchange triggers the dissociation of the Galpha subunit from the Gbeta-gamma dimer and the receptor. Galpha-GTP and Gbeta-gamma, can then modulate different signalling cascades and effector proteins, while the receptor is able to activate another G protein, resulting in an amplification cascade. The Galpha subunit will eventually hydrolyze the attached GTP to GDP by its inherent enzymatic activity, allowing it to reassociate with Gbeta-gamma and start a new cycle.,
Reviewed: Castagnoli, L, 2008-11-06 12:55:54
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| biopax3:xref | |
| biopax3:dataSource | |
| biopax3:displayName |
G-protein activation
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| biopax3:organism | |
| biopax3:pathwayComponent |
http://www.reactome.org/biopax/48887BiochemicalReaction3539,
http://www.reactome.org/biopax/48887BiochemicalReaction3540,
http://www.reactome.org/biopax/48887BiochemicalReaction3541,
http://www.reactome.org/biopax/48887BiochemicalReaction3542,
http://www.reactome.org/biopax/48887BiochemicalReaction3543,
http://www.reactome.org/biopax/48887BiochemicalReaction3544
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| biopax3:pathwayOrder |
http://www.reactome.org/biopax/48887PathwayStep4463,
http://www.reactome.org/biopax/48887PathwayStep4464,
http://www.reactome.org/biopax/48887PathwayStep4462,
http://www.reactome.org/biopax/48887PathwayStep4467,
http://www.reactome.org/biopax/48887PathwayStep4465,
http://www.reactome.org/biopax/48887PathwayStep4466
|