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Authored: Jassal, B, 2004-12-15 13:08:03,
Edited: Orlic-Milacic, M, 2012-02-10,
Reviewed: Joutel, A, 2004-12-15,
Similar to NOTCH1, NOTCH4 is activated by delta-like and jagged ligands (DLL/JAG) expressed in trans on a neighboring cell. The activation triggers cleavage of NOTCH4, first by ADAM10 at the S2 cleavage site, then by gamma-secretase at the S3 cleavage site, resulting in the release of the intracellular domain of NOTCH4, NICD4, into the cytosol. NICD4 subsequently traffics to the nucleus where it acts as a transcriptional regulator.
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Signaling by NOTCH4
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