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Authored: Garapati, P V, 2010-10-29,
Edited: Garapati, P V, 2010-10-29,
Major histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular bacteria or tumor-associated antigens. They bind peptide fragments of these proteins and presenting them to CD8+ T cells at the cell surface. This enables cytotoxic T cells to identify and eliminate cells that are synthesizing abnormal or foreign proteins. MHC class I is a trimeric complex composed of a polymorphic heavy chain (HC or alpha chain) and an invariable light chain, known as beta2-microglobulin (B2M) plus an 8-10 residue peptide ligand. Represented here are the events in the biosynthesis of MHC class I molecules, including generation of antigenic peptides by the ubiquitin/26S-proteasome system, delivery of these peptides to the endoplasmic reticulum (ER), loading of peptides to MHC class I molecules and display of MHC class I complexes on the cell surface.,
Reviewed: Elliott, T, 2011-02-10
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| biopax3:xref |
http://identifiers.org/pubmed/12495737,
http://identifiers.org/pubmed/17055423,
http://identifiers.org/pubmed/17145306,
http://identifiers.org/pubmed/18243674,
http://identifiers.org/pubmed/18641646,
http://identifiers.org/pubmed/18926908,
http://identifiers.org/pubmed/19261456,
http://identifiers.org/pubmed/8717519,
urn:biopax:RelationshipXref:GENE ONTOLOGY_GO:0002474,
urn:biopax:UnificationXref:REACTOME DATABASE ID_983169,
urn:biopax:UnificationXref:REACTOME_REACT_75820_1
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Class I MHC mediated antigen processing & presentation
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