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Authored: Jassal, B, 2011-10-14,
Edited: Jassal, B, 2011-10-14,
Reviewed: D'Eustachio, P, 2012-05-14,
Sulfatase activity requires a unique posttranslational modification (PTM) of a catalytic cysteine residue into a formylglycine. This modification is impaired in patients with multiple sulfatase deficiency (MSD) due to defects in the SUMF1 (sulfatase-modifying factor 1) gene responsible for this PTM. SUMF2 can inhibit the activity of SUMF1 thereby providing a mechanism for the regulation of sulfatase activation (Ghosh 2007, Diez-Roux & Ballabio 2005).
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The activation of arylsulfatases
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