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| biopax3:comment |
Authored: Orlic-Milacic, M, 2012-04-04,
Edited: Jassal, B, 2012-04-10,
In the nucleus, SMAD2/3:SMAD4 heterotrimer complex acts as a transcriptional regulator. The activity of SMAD2/3 complex is regulated both positively and negatively by association with other transcription factors (Chen et al. 2002, Varelas et al. 2008, Stroschein et al. 1999, Wotton et al. 1999) . In addition, the activity of SMAD2/3:SMAD4 complex can be inhibited by nuclear protein phosphatases and ubiquitin ligases (Lin et al. 2006, Dupont et al. 2009).,
Reviewed: Huang, Tao, 2012-05-14
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| biopax3:xref |
http://identifiers.org/pubmed/10199400,
http://identifiers.org/pubmed/10531062,
http://identifiers.org/pubmed/12150994,
http://identifiers.org/pubmed/16751101,
http://identifiers.org/pubmed/18568018,
http://identifiers.org/pubmed/19135894,
urn:biopax:RelationshipXref:GENE ONTOLOGY_GO:0006351,
urn:biopax:UnificationXref:REACTOME DATABASE ID_2173793,
urn:biopax:UnificationXref:REACTOME_REACT_121061_1
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| biopax3:displayName |
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
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| biopax3:pathwayOrder |