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Authored: Matthews, L, 2008-04-25 11:29:13,
DNA fragmentation in response to apoptotic signals is achieved through the activity of two apoptotic nucleases, termed DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in Widlak and Garrard, 2005). These endonucleases cleave chromatin producing 3'-hydroxyl groups and 5'-phosphate residues. 50-300 kb cleavage products are produced followed by internucleosomal DNA fragmentation. Although the activities of DFF and Endo G are similar, they reside in different locations within the cell and are regulated in different ways.,
Edited: Matthews, L, 2008-05-18 15:19:12,
Reviewed: Widlak, P, 2008-04-25 14:11:44
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Apoptosis induced DNA fragmentation
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