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|---|---|
| rdf:type | |
| biopax3:comment |
Authored: Jassal, B, 2008-05-19 12:57:01,
CYP2E1 can metabolize and activate a large number of solvents and industrial monomers as well as drugs. This quality of CYP2E1 may make it an important determinant of human susceptibility to the toxic effects of industrial and environmental chemicals. Typical CYP2E1 substrates include acetaminophen, benzene, CCl4, halothane, ethanol and vinyl chloride. CYP2E1 contributes to oxidative stress by producing oxidising species called reactive oxygen species (ROS) which can lead to damage to mitochondria, DNA and initiate lipid peroxidation or even cell death.,
Edited: Jassal, B, 2008-05-19 12:57:01,
Reviewed: D'Eustachio, P, 2008-05-28 08:30:54
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| biopax3:xref | |
| biopax3:dataSource | |
| biopax3:displayName |
CYP2E1 reactions
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| biopax3:organism | |
| biopax3:pathwayComponent |
http://www.reactome.org/biopax/48887BiochemicalReaction5163,
http://www.reactome.org/biopax/48887BiochemicalReaction5164,
http://www.reactome.org/biopax/48887BiochemicalReaction5165,
http://www.reactome.org/biopax/48887BiochemicalReaction5166,
http://www.reactome.org/biopax/48887BiochemicalReaction5167,
http://www.reactome.org/biopax/48887BiochemicalReaction5168
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| biopax3:pathwayOrder |
http://www.reactome.org/biopax/48887PathwayStep6456,
http://www.reactome.org/biopax/48887PathwayStep6459,
http://www.reactome.org/biopax/48887PathwayStep6458,
http://www.reactome.org/biopax/48887PathwayStep6461,
http://www.reactome.org/biopax/48887PathwayStep6460,
http://www.reactome.org/biopax/48887PathwayStep6457
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