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biopax3:comment |
Authored: Williams, MG, 2011-09-14,
Edited: Williams, MG, 2011-08-12,
In the <i>de novo</i> synthesis of phosphatidic acid (PA), lysophosphatidic acid (LPA) is initially formed by the esterification of <i>sn-1</i> by glycerol 3-phosphate acyltransferase (GPAT) from glycerol 3-phosphate (G3P). Next, LPA is converted to PA by a LPA acyltransferase (AGPAT, also known as LPAAT). In addition to this, PA is also formed when phosphatidylcholine (PC) is hydrolyzed by phospholipase D1/2 (PLD1/2). PA is involved in acyl chain remodeling via cleavage by phospholipases followed by reacylation by acyltransferases (Ghomashchi et al. 2010, Singer et al. 2002, Prasad et al. 2011, Shindou & Shimizu 2009, Cao et al. 2006).,
Reviewed: Wakelam, Michael, 2012-05-14
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