| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:controlType |
ACTIVATION
|
| biopax3:controlled | |
| biopax3:comment |
Activated PKA promotes the closing of inward rectifying potassium channels thus leading to depolarization of the plasma membrane of the beta cell and, via opening of voltage-gated calcium channels, causing exocytosis of insulin granules. PKA presumably acts by phosphorylating the potassium channel, but this is not certain.
|
| biopax3:xref | |
| biopax3:controller | |
| biopax3:dataSource | |
| biopax3:displayName |
'PKA catalytic subunit [cytosol]' positively regulates 'Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels)'
|