Source:http://www.reactome.org/biopax/48887BiochemicalReaction952
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Authored: Akkerman, JW, 2009-09-04,
Edited: Jupe, S, 2010-09-01,
Reviewed: Heemskerk, JW, 2010-09-01,
The beta 3 integrin cytoplasmic tail binds SH2-containing protein (SHC), an adapter in Ras signaling. Phosphorylation of Y785 may be necessary for binding; phosphorylation of T779 inhibits SHC binding. Mice expressing a mutated beta 3 where Y773 and Y785 have been mutated to F exhibit rebleeding from tail wounds and subtle defects in clot retraction and platelet aggregation.
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Activated integrin alphaIIb beta3 binds SHC1
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