Source:http://www.reactome.org/biopax/48887BiochemicalReaction944
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Authored: Garapati, P V, 2008-06-16 17:13:06,
Edited: Garapati, P V, 2008-06-16 17:13:06,
Reviewed: Shattil, SJ, 2008-09-16 06:21:39,
The co-localization of FAK with integrins in focal adhesions and the actin cytoskeleton is essential for the activation and phosphorylation of FAK. <br>FAK has six tyrosine phosphorylation sites and tyrosine 397 is the main auto-phosphorylation site present upstream of the kinase domain.
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Autophosphorylation of FADK1 at Y397
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