Source:http://www.reactome.org/biopax/48887BiochemicalReaction943
| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
As integrins do not have an intrinsic catalytic activity, the signals initiated by the ECM-integrin interactions are transduced into cells through the integrin bound protein-tyrosine kinases. Focal adhesion kinase 1 (FADK1, FAK) is one of the protein tyrosine kinases that plays a prominent role in integrin signaling. FAK has been implicated in controlling cell motility and transmitting a cell survival signal from ECM. <br><br>FAK is recruited to sites of integrin clustering by directly binding to integrin associated c-Src.<br>,
Authored: Garapati, P V, 2008-06-16 17:13:06,
Edited: Garapati, P V, 2008-06-16 17:13:06,
Reviewed: Shattil, SJ, 2008-09-16 06:21:39
|
| biopax3:xref | |
| biopax3:dataSource | |
| biopax3:displayName |
Translocation of FADK1 to Focal complexes
|
| biopax3:left | |
| biopax3:right |