Source:http://www.reactome.org/biopax/48887BiochemicalReaction933
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Authored: Garapati, P V, 2008-06-16 17:13:06,
Edited: Garapati, P V, 2008-06-16 17:13:06,
Reviewed: Shattil, SJ, 2008-09-16 06:21:39,
Signals from agonist receptors (such as GPVI) trigger the production of PIP3, DAG, cAMP and elevated Ca++ levels. This leads to the activation and translocation of active Rap1-GTP to the plasma membrane. Rap-GEFs stimulate the replacement of GDP for GTP, activating Rap1. Several Rap1 GEFs have been identified enabling Rap1 to respond to diverse stimuli. CalDAG-GEFs activate Rap1 in response to calcium and DAG, downstream of Phospholipase C. EPAC (exchange proteins directly activated by cAMP) GEFs are activated by binding cAMP.
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http://identifiers.org/pubmed/12585966,
http://identifiers.org/pubmed/15334074,
http://identifiers.org/pubmed/15469846,
http://identifiers.org/pubmed/16076873,
http://identifiers.org/pubmed/16757337,
urn:biopax:UnificationXref:REACTOME DATABASE ID_354173,
urn:biopax:UnificationXref:REACTOME_REACT_15507_4
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Activation of Rap1 by cytosolic GEFs
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