Source:http://www.reactome.org/biopax/48887BiochemicalReaction927
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Authored: Akkerman, JW, 2009-09-04,
Edited: Jupe, S, 2009-11-03,
Reviewed: Harper, MT, 2009-11-02,
Reviewed: Jones, ML, 2009-11-02,
Reviewed: Poole, AW, 2009-11-02,
Vav interacts directly with PIP2 and PIP3, with a fivefold selectivity for PIP3 over PIP2. PIP3 gives a twofold stimulation of Vav1 GEF activity while PIP2 leads to 90% inhibition. Binding probably occurs through the PH domain, known to bind phosphoinositides.
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PIP2 inhibits Vav
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