Source:http://www.reactome.org/biopax/48887BiochemicalReaction924
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Authored: Akkerman, JW, 2009-06-03,
Edited: Jupe, S, 2009-11-03,
Reviewed: Harper, MT, 2009-11-02,
Reviewed: Jones, ML, 2009-11-02,
Reviewed: Poole, AW, 2009-11-02,
SLP-76 has a well-established role in recruitment of PLC gamma 1 in immunoreceptor signalling; its role in the recruitment of PLC gamma 2 in integrin signalling is less clear. Results from SLP-76 null mice imply a functional role in GPVI signalling. Platelets from SLP-76 null mice exhibit a marked reduction in spreading and a decrease in whole cell phosphotyrosine levels when adhered to a fibrinogen-coated surface. In vivo reconstitution of SLP-76 by retroviral gene transfer corrects bleeding diathesis and restores normal responses to both collagen and fibrinogen (Judd et al., 2000).
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SLP-76 stimulates PLC gamma 2
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