Source:http://www.reactome.org/biopax/48887BiochemicalReaction917
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Authored: Akkerman, JW, 2009-09-04,
Edited: Jupe, S, 2010-06-07,
Reviewed: Kunapuli, SP, 2010-06-07,
The SH2 region of Vav1 binds to Syk at a site including phosphorylated tyrosine Y348. Mutation of this residue to F abolishes binding and subsequent Vav1 phosphorylation. Vav2 has also been shown to bind Syk.
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Syk binds Vav
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