Source:http://www.reactome.org/biopax/48887BiochemicalReaction914
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biopax3:comment |
Syk binds to the phosphorylated ITAM motif of Fc epsilon R1 gamma chain, each SH2 domain binding a phosphorylated tyrosine. Unlike Zap70, Syk appears to autophosphorylate, so does not require Src family kinases for activation.
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Binding of Syk tyrosine kinase
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