Source:http://www.reactome.org/biopax/48887BiochemicalReaction90
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Authored: Orlic-Milacic, M, 2012-04-04,
E3 ubiqutin ligases RNF111 (Arkadia) (Levy et al. 2007, Nagano et al. 2007) and SMURF2 (Bonni et al. 2001) ubiquitinate SKI/SKIL transcriptional repressors bound to activated SMAD2/3. The role of RNF111 was inferred from experiments that used recombinant mouse RNF111 and endogenous human SMADs and SKI/SKIL. The role of SMURF2 was inferred from experiments involving human proteins only.,
Edited: Jassal, B, 2012-04-10,
Reviewed: Huang, Tao, 2012-05-14
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Ubiquitination of SKI/SKIL by RNF111/SMURF2
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6.3.2.19
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