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Authored: Orlic-Milacic, M, 2012-04-04, Edited: Jassal, B, 2012-04-10, Reviewed: Huang, Tao, 2012-05-14, SMAD2/3:SMAD4 heterotrimer binds SMAD binding site in the promoter of JUNB transcription factor and in cooperation with AP-1 transcription factors, which bind to an adjacent promoter element, stimulates transcription of JUNB gene (Wong et al. 1999).
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SMAD2/3:SMAD4 complex positively regulates JUNB transcription
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