Source:http://www.reactome.org/biopax/48887BiochemicalReaction863
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Authored: Akkerman, JW, 2009-09-04,
Edited: Jupe, S, 2010-06-07,
LDL stimulation of platelets leads to increased p38 MAPK activation by phosphorylation. An Src family kinase is responsible for this; Fgr is a strong candidate as it is known to bind the LDL receptor in platelets responding to LDL and in chemoattractant-induced degranulation of neutrophils activation of p38 MAPK is blocked by a triple Hck/Fgr/Lyn knockout. However fMLP-stimulated phosphorylation of MAPKs in a double hck/fgr PMNs was observed to be normal, suggesting that Lyn, rather than Fyn, is involved.,
Reviewed: Kunapuli, SP, 2010-06-07
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Fgr may phosphorylate p38 MAPK
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2.7.10.2
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