Source:http://www.reactome.org/biopax/48887BiochemicalReaction859
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Authored: Akkerman, JW, 2009-09-04,
Edited: Jupe, S, 2010-06-07,
Reviewed: Kunapuli, SP, 2010-06-07,
Sustained calcium signalling in lymphocytes and platelets requires the uptake of extracellular calcium when intracellular stores are depleted. The process whereby intracellular calcium depletion stimulates calcium uptake is often referred to as Store-operated calcium entry (SOCE). Store depletion is sensed by stromal interaction molecule 1 (STIM1), which then translocates to the plasma membrane and associates with 2 dimers of Orai1 to form a calcium-release activated calcium (CRAC) channel.
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http://identifiers.org/pubmed/16921385,
http://identifiers.org/pubmed/17703229,
http://identifiers.org/pubmed/17965774,
http://identifiers.org/pubmed/18187424,
http://identifiers.org/pubmed/18596693,
http://identifiers.org/pubmed/18769136,
http://identifiers.org/pubmed/18952890,
http://identifiers.org/pubmed/19249086,
urn:biopax:UnificationXref:REACTOME DATABASE ID_434700,
urn:biopax:UnificationXref:REACTOME_REACT_23904_3
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STIM1 activation of CRAC
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