Source:http://www.reactome.org/biopax/48887BiochemicalReaction852
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Authored: Akkerman, JW, 2009-06-03,
Cyclic GMP phosphodiesterase are hydrolases selective for cAMP (PDE4, 7 and 8), cGMP (PDE5, 6 and 9) or able to hydrolyse both cAMP and cGMP (PDE1, 2, 3, 10 and 11). Â The dual-specificity PDEs allow for cross-regulation of the cAMP and cGMP pathways, e.g. PDE2 can hydrolyse both, but binding of cGMP to the regulatory GAF-B domain increases cAMP affinity and hydrolysis.<br>PDE2, 3 and 5 are expressed in platelets.,
Edited: Jupe, S, 2010-06-07,
Reviewed: Kunapuli, SP, 2010-06-07
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cGMP is degraded by PDEs
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3.1.4.35
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