Source:http://www.reactome.org/biopax/48887BiochemicalReaction849
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Authored: Akkerman, JW, 2009-06-03,
Edited: Jupe, S, 2010-06-07,
Reviewed: Kunapuli, SP, 2010-06-07,
Soluble guanylate cyclase (sGC) is a heterodimeric hemoprotein that selectively binds Nitric Oxide (NO). NO binding stimulates the synthesis of cGMP, which then binds to phosphodiesterases (PDE), ion-gated channels, and cGMP-dependent protein kinases (cGK) to regulate several physiological functions including vasodilation, platelet aggregation and neurotransmission.
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NO binds to Guanylate Cyclase
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