Source:http://www.reactome.org/biopax/48887BiochemicalReaction826
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Authored: Jakobi, R, 2008-02-05 11:04:14,
Edited: Matthews, L, 2008-02-03 20:50:13,
Edited: Matthews, L, 2008-05-18 16:50:19,
Reviewed: Chang, E, 2008-05-21 00:05:41,
The subcellular localization of PAK-2 is controlled by nuclear localization and nuclear export signal motifs (Jakobi et al.,2003). The regulatory domain contains a nuclear export signal motif that prevents the nuclear accumulation of full-length PAK-2. The activating proteolytic cleavage disrupts the nuclear export signal in PAK-2 and removes most its regulatory domain. The resulting activated PAK-2p34 fragment contains a nuclear localization signal and translocates to and is retained in the nucleus (Jakobi et al.,2003).
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Proteolytic PAK-2p34 fragment translocates to the nucleus
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