Source:http://www.reactome.org/biopax/48887BiochemicalReaction824
| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
Authored: Jakobi, R, 2008-02-05 11:04:14,
Edited: Matthews, L, 2008-02-03 20:50:13,
Edited: Matthews, L, 2008-05-23 07:02:49,
Reviewed: Chang, E, 2008-05-21 00:05:41,
p21-activated protein kinase (PAK-2), also known as gamma-PAK, is cleaved by caspase-3 during apoptosis and plays a role in regulating cell death. Cleavage produces two peptides; 1-212 containing most of the regulatory domain and 213-524 containing 34 amino acids of the regulatory domain as well as the catalytic domain (Walter et al., 1998). Proteolytic cleavage of PAK by caspase-3 creates the constitutively active PAK-2p34 fragment (Jakobi et al., 2003). Evidence for this reaction comes from experiments using both human and rabbit proteins.
|
| biopax3:xref | |
| biopax3:dataSource | |
| biopax3:displayName |
Cleavage of PAK-2 at 212
|
| biopax3:eCNumber |
3.4.22
|
| biopax3:left | |
| biopax3:right |