Source:http://www.reactome.org/biopax/48887BiochemicalReaction823
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Authored: Matthews, L, 2008-01-29 12:03:24,
Edited: Matthews, L, 2008-01-29 12:04:16,
Edited: Matthews, L, 2008-05-02 11:33:14,
Reviewed: Widlak, P, 2008-05-07 23:54:18,
The DFF40 cleaves DNA substrates to generate fragments possessing ends with 5â??-phosphate and 3â??-hydroxyl groups, and generates exclusively double strand breaks (primarily blunt ends). It has some sequence preferences on naked DNA substrates and prefers purine/pyrimidine blocks with rotational symmetry (Widlak et al., 2000). DFF is both a deoxyribonucleotide-specific and a double-strand-specific endonuclease (Hanus et al., 2008).
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Cleavage of DNA by DFF40
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