Source:http://www.reactome.org/biopax/48887BiochemicalReaction811
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Authored: Schulze-Osthoff, K, 2008-05-18 10:00:05,
Claspin is cleaved by caspase-7 during the initiation of apoptosis following DNA damage (Clarke et al., 2005). Claspin is cleaved at a single aspartate residue into a large N-terminal fragment and a smaller C-terminal fragment that contain different functional domains. Only the large N-terminal fragment retains Chk1 binding activity. The smaller C-terminal fragment associates with DNA and inhibits the DNA-dependent phosphorylation of Chk1 associated with its activation indicating that cleavage of Claspin by caspase-7 inactivates the Chk1 signaling pathway (Clarke et al., 2005).,
Edited: Matthews, L, 2008-06-02 08:00:47,
Reviewed: Ranganathan, S, 2008-06-11 19:13:33
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Caspase-mediated cleavage of claspin
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3.4.22
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