Source:http://www.reactome.org/biopax/48887BiochemicalReaction810
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Authored: Schulze-Osthoff, K, 2008-05-18 10:00:05,
Caspase-mediated cleavage of Mst3 activates its intrinsic kinase activity. Proteolytic removal of the COOH-terminal domain promotes nuclear translocation of its kinase domain. Ectopic expression of COOH-terminal truncated Mst3 results in DNA fragmentation and morphological changes characteristic of apoptosis (Huang et al., 2002).,
Edited: Matthews, L, 2008-05-27 07:43:39,
Reviewed: Ranganathan, S, 2008-06-11 19:13:33
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Caspase-mediated cleavage of MST3
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3.4.22
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