Source:http://www.reactome.org/biopax/48887BiochemicalReaction806
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Authored: Schulze-Osthoff, K, 2007-09-03 07:52:18,
Edited: Matthews, L, 2007-09-03 07:38:20,
Edited: Matthews, L, 2007-10-09 13:44:38,
Edited: Matthews, L, 2007-11-11 23:40:56,
Farnesyltransferase/geranyl-geranyltransferase catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. This enzyme complex consists of a heterodimer of an alpha and a beta subunit. The alpha subunit is thought to function in the formation of a stable complex with the substrate. This alpha subnit is cleaved by caspase 3. Expression of the cleavage product (60-379) induces cell death (Kim et al., 2001).,
Reviewed: Ranganathan, S, 2007-11-23 00:10:26
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Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha
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3.4.22
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