Source:http://www.reactome.org/biopax/48887BiochemicalReaction787
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Authored: Schulze-Osthoff, K, 2007-09-03 07:52:18,
Edited: Matthews, L, 2007-09-03 07:38:20,
Edited: Matthews, L, 2007-10-09 13:44:38,
Edited: Matthews, L, 2007-11-11 23:40:56,
Reviewed: Ranganathan, S, 2008-06-11 19:13:33,
The cleavage of E-cadherin at both the intracellular and extracellular domains likely contributes to the disruption of cadherin-mediated cell-cell contacts in apoptotic cells. Loss of cell contact is necessary for cell rounding and exit from the epithelium (Steinhusen et al., 2001).
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Caspase-mediated cleavage of E-Cadherin
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3.4.22
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