Source:http://www.reactome.org/biopax/48887BiochemicalReaction701
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The binding of the primer recognition complex involves the loading of proliferating cell nuclear antigen (PCNA). Replication Factor C transiently opens the PCNA toroid in an ATP-dependent reaction, and then allows PCNA to re-close around the double helix adjacent to the primer terminus. This leads to the formation of the "sliding clamp".
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Loading of PCNA - Sliding Clamp Formation
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