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48887BiochemicalReaction660

Source:http://www.reactome.org/biopax/48887BiochemicalReaction660

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Authored: Matthews, L, 2008-08-24 03:27:07, Edited: Matthews, L, 2008-08-24 03:27:07, Reviewed: Cheeseman, IM, 2008-09-02 04:22:10, The human kinetochore, is a complex proteinaceous structure that assembles on centromeric DNA and mediates the association of mitotic chromosomes with spindle microtubule in prometaphase. The molecular composition of the human kinetochore is reviewed in detail in Cheeseman et al., 2008. This complex structure is composed of numerous protein complexes and networks including: the constitutive centromere-associated network (CCAN) containing several sub-networks such as (CENP-H, I, K), (CENP-50/U, O, P, Q, R), the KMN network ( containing KNL1, the Mis12 complex, and the Ndc80 complex), the chromosomal passenger complex, the mitotic checkpoint complex, the nucleoporin 107-160 complex and the RZZ complex. At prometaphase, following breakdown of the nuclear envelope, the kinetochores of condensed chromosomes begin to to interact with spindle microtubules. In humans, 15-20 microtubules are bound to each kinetochore (McEwen et al., 2001). Recently, it has been shown that the core kinetochore-microtubule attachment site is within the KMN network and is likely to be formed by two closely apposed low-affinity microtubule-binding sites, one in the Ndc80 complex and a second in KNl1 (Cheeseman et al., 2006).
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Kinetochore capture of astral microtubules
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