Linked Life Data

48887BiochemicalReaction651

Source:http://www.reactome.org/biopax/48887BiochemicalReaction651

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Authored: Jupe, S, 2010-07-20, Collagen type VI forms dimers and tetramers before secretion (Furthmayr et al. 1983, von der Mark et al. 1984, Engel et al. 1985, Colombatti et al. 1987). The monomers associate in antiparallel with a 30nm axial shift, intertwining 4 or 5 times (Furthmayr et al. 1983). These associate laterally to form tetramers (Furthmayr et al. 1983, von der Mark et al. 1984)The tetramers associate to form microfibrils in a non-covalent manner, presumed to be mediated through A domain interactions (Baldock et al. 2003). Collagen type VI chains are extensively post translationally modifed by the hydroxylation of proline and lysine residues (Myllyharju & Kivirikko 2004) and subsequent glycosylation of hydroxylysine, thought to be essential for tetramer formation and secretion (Sipila et al. 2007)., Edited: Jupe, S, 2012-05-14, Reviewed: Canty-Laird, EG, 2012-05-24
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Dimerization of procollagen type VI
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