Source:http://www.reactome.org/biopax/48887BiochemicalReaction610
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Authored: Jassal, B, 2010-09-23,
Edited: Jassal, B, 2010-09-23,
Reviewed: He, L, 2010-11-15,
The 5-hydroxytryptamine receptor (5-HT3) family are members of the superfamily of LGICs. Five receptors (5-HT3A-E) form a heteropentamer. Binding of the neurotransmitter 5-hydroxytryptamine (serotonin) to the 5-HT3 receptor complex opens the channel, which, in turn, leads to an excitatory response in neurons and is permeable to sodium, potassium, and calcium ions (Miyake et al, 1995; Davies et al, 1999; Niesler et al, 2007).
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The 5-HT3 receptor complex is permeable to Na+,K+, and Ca2+ when it binds serotonin (5-HT)
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