Source:http://www.reactome.org/biopax/48887BiochemicalReaction5351
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Authored: Mahajan, SS, 2009-10-29,
Edited: Gillespie, ME, 2009-06-02 00:56:21,
Raf is a downstream effector of ras. Raf is activated upon phosphorylation at S338, oligomerization and membrane localization. Membrane localization is facilitated by ras. Interaction of ras with raf is a necessary step but not sufficient for raf activation. Other unknown protein partner interactions are required for raf activation. Raf further activates MAP kinase.,
Reviewed: Tukey, D, 2009-11-17
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Raf activation
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