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Authored: D'Eustachio, P, 2012-03-14, Edited: D'Eustachio, P, 2012-03-16, Reviewed: Jassal, B, 2012-03-16, The ABCB1 transporter associated with the plasma membrane mediates the ATP-dependent efflux of a variety of xenobiotic molecules. Its ability to transport abacavir is inferred from studies of the corresponding mouse protein (Shaik et al. 2007).
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ABCB1-mediated abacavir efflux
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abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate
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3.6.3.44
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