Source:http://www.reactome.org/biopax/48887BiochemicalReaction5256
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Authored: May, B, 2011-08-07,
Carbonic anhydrase I (CA1, Khalifah 1971, Pesando 1975, Simonsson et al. 1982, Ren & Lindskog 1992) and carbonic anhydrase II (CA2, Tibell et al. 1984, Jones & Shaw 1983, Ghannam et al. 1986) hydrate carbon dioxide (CO2) to yield bicarbonate (HCO3-) and a proton (H+). During the reaction a hydroxyl group bound by the zinc ion (Zn2+) attacks the CO2 molecule in the active site to directly form HCO3- (reviewed in Lindskog 1997). The HCO3- is displaced by water, which is then deprotonated by a histidine residue to recreate the Zn2+:hydroxyl group. Depending on the concentrations of reactants the reaction is reversible.,
Edited: May, B, 2011-08-07,
Reviewed: Jassal, B, 2012-04-27
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| biopax3:xref |
http://identifiers.org/pubmed/1554744,
http://identifiers.org/pubmed/234739,
http://identifiers.org/pubmed/3080418,
http://identifiers.org/pubmed/4994926,
http://identifiers.org/pubmed/6407977,
http://identifiers.org/pubmed/6433979,
http://identifiers.org/pubmed/6819139,
http://identifiers.org/pubmed/9336012,
urn:biopax:UnificationXref:REACTOME DATABASE ID_1475435,
urn:biopax:UnificationXref:REACTOME_REACT_121371_1
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Carbonic Anhydrase I/II Hydrates Carbon Dioxide
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4.2.1.1
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