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Edited: D'Eustachio, P, 2006-03-11 18:40:17, Reviewed: D'Eustachio, P, 2008-05-28 08:30:54, Sulfonation of the xenobiotic N-hydroxy-2-acetylaminofluorene converts it to a potent carcinogen. SULT1A2 (Glatt 2000) and SULT1C1 and 1C2 (Sakakibara et al. 1998) catalyze this reaction.
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N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP
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2.8.2
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