Source:http://www.reactome.org/biopax/48887BiochemicalReaction5193
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Authored: Jassal, B, 2008-05-19 12:57:01,
Edited: Jassal, B, 2008-05-19 12:57:01,
Reviewed: D'Eustachio, P, 2008-05-28 08:30:54,
Tamoxifen (TAM) is an antiestrogen and currently used extensively for breast cancer therapy. FMOs, especially FMO1 can N-oxidze TAM to tamoxifen N-oxide (TNO). TNO can be reduced back to TAM by the P450 system. TNO appears to be just as potent as TAM but with fewer side-effects so this metabolic cycling could play a part in the use of TNO in the treatment of breast cancer.
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FMO1 N-oxidizes the anti-cancer drug tamoxifen
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1.14.13.8
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