Source:http://www.reactome.org/biopax/48887BiochemicalReaction5172
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Authored: Jassal, B, 2008-05-19 12:57:01,
Edited: Jassal, B, 2008-05-19 12:57:01,
Reviewed: D'Eustachio, P, 2008-05-28 08:30:54,
The CYP3A family are the most abundantly expressed P450s in human liver, accounting for around 50% of xenobiotic drug metabolism. CYP3A4 is the most abundant member of the family and possesses broad specificity to a range of xenobiotics. Loperamide (LOP), an antidiarrheal, is mainly metabolized to desmethylloperamide (DLOP) through the N-demethylation pathway. This initial N-demethylation is carried out by CYP3A4.
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CYP3A4 can N-demethylate loperaminde
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