Source:http://www.reactome.org/biopax/48887BiochemicalReaction517
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Authored: Jassal, B, 2010-03-19,
Edited: Jassal, B, 2010-03-19,
Reviewed: He, L, 2010-05-10,
The human gene SLC22A2 encodes the organic cation transporter OCT2. It is expressed in a variety of tissues, especially the kidney and placenta. OCT2 can mediate the reversible transport of a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN) and 4-(4-(dimethylamino)styryl)-N-methylpyridinium (Gorboulev V et al, 1997). Pharmaceuticals that up-regulate OCT2 in the kidney can increase the renal excretion of cationic drugs.
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OCT2 mediates tubular uptake of organic cations in the kidney
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