Source:http://www.reactome.org/biopax/48887BiochemicalReaction5150
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Authored: Jassal, B, 2005-02-23 15:02:50,
Edited: Jassal, B, 2010-05-27,
Reviewed: D'Eustachio, P, 2010-05-08,
The principal conjugate of bilirubin in bile is bilirubin diglucuronide. The monmeric form of UGT1A1 (Bilirubin UDP-glucuronyltransferase) only conjugates the first step of bilirubin conjugation to form the monoglucuronide. A tetrameric form of UGT1A1 can convert bilirubin to both the monoglucuronide and the diglucuronide.
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Bilirubin monoglucuronide is conjugated to bilirubin diglucuronide
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bilirubin monoglucuronide + UDP-glucuronic acid => bilirubin diglucuronide + UDP
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2.4.1.17
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