Source:http://www.reactome.org/biopax/48887BiochemicalReaction5090
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Authored: Jassal, B, 2008-10-01 13:18:42,
Edited: Jassal, B, 2008-01-08 13:51:41,
Reviewed: D'Eustachio, P, 2008-05-28 08:30:54,
The human iodotyrosine dehalogenase 1 (DEHAL1) gene is composed of six exons. Two isoforms (DEHAL1 and DEHAL1B) have been published, both of which have a nitroreductase domain and arise from differential splicing in exon 5. The DEHAL1 isoform is a transmembrane protein that catalyzes the NADPH-dependent deiodination of monoiodotyrosine (MIT) and diiodotyrosine (DIT).
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Monoiodinated tyrosine can be deiodinated
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1
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