Source:http://www.reactome.org/biopax/48887BiochemicalReaction5042
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Authored: D'Eustachio, P, 2003-06-24 00:00:00,
Cytosolic argininosuccinate synthase catalyzes the reaction of aspartate, citrulline, and ATP to form argininosuccinate, AMP, and pyrophosphate. The function of the human enzyme in vivo is inferred from the hypercitrullinemia observed in patients with defective forms of the enzyme (e.g., Engel et al. 2009). The enzyme is active as a homotetramer (Oâ??Brien 1980; Karlberg et al. 2008).,
Edited: D'Eustachio, P, 2003-06-24 00:00:00
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ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate
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6.3.4.5
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