Source:http://www.reactome.org/biopax/48887BiochemicalReaction4981
| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
Cytosolic branched-chain-amino-acid aminotransferase (BCAT1) catalyzes the reversible reactions of leucine, isoleucine, or valine with alpha-ketoglutarate (2-oxoglutarate) to form alpha-ketoisocaproate, alpha-keto-beta-methylvalerate, or a-ketoisovalerate, respectively, and glutamate. The active enzyme is a homodimer. Hutson and colleagues have argues that cytosolic BCAT1 plays a major role in the generation of glutamate involved in synaptic transmission in neural tissue (Goto et al. 2005).
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| biopax3:xref | |
| biopax3:dataSource | |
| biopax3:displayName |
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1]
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| biopax3:eCNumber |
2.6.1.42
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| biopax3:left | |
| biopax3:right |