Source:http://www.reactome.org/biopax/48887BiochemicalReaction4882
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Cytosolic CTP synthase 2 (CTPS) catalyzes the reaction of UTP, glutamine, ATP and water to form CTP, glutamate, ADP, and orthophosphate (Han et al. 2005; van Kuilenberg et al. 2000). Unpublished X-ray crystallographic data suggest that the enzyme is a tetramer (PDB 3IHL). Both CTPS2 and a second human gene product, CPTS, have CTP synthase activity in various test systems; their relative contributions to CTP metabolism in the body is not clear.
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UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]
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amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTP)
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6.3.4.2
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